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Noki4 started the topic Medication interactions and warnings in the forum Treatment Options for Pain 10 years, 5 months ago
I recently watched a presentation regarding chronic pain. During the presentation the presenter used the medication Fentanyl as an example of making sure everyone understood the importance of talking to your healthcare providers and pharmacist about possible interactions. The presenter said that if one is prescribed Fentanyl that they should not eat grapefruit or drink grapefruit juice.
According to information I found, grapefruit could possibly hinder the breaking down of the fentanyl.This really got me to thinking about how we are given potential interaction information and I was curious about the best way that we can make sure we are given all the needed information when prescribed medications.
I contacted my pharmacy and spoke with my pharmacist and explained to them that I was wondering how it is decided what information is given as warnings or interactions when a prescription is filled.
I used the grapefruit and fentanyl as an example. When he came back from checking his computer for the information I was told that it is considered an undocumented issue in the system that they use for showing interactions when filling prescriptions. He said that meant there has been no documented cases of anyone having an issue but there was the possibly it could happen. Since it is considered undocumented that means that they would not put a warning on the medication when it was filled.He went on to tell me that is why it is a wise and good practice to always read the inserts of any new medications, not just pain medications because things could be listed from the manufacturer of the medication.
It is not my intentions to cause worry or upset for anyone who may be using this medication.
My only intentions is to share that I find it interesting what information is given to the consumer.
Now that I have learned about undocumented issues, I think I will feel more comfortable in the future asking my pharmacist for any undocumented warnings that may be in the computer.
I found some online links that may be helpful:
FDA: http://www.fda.gov/forconsumers/consumerupdates/ucm292276.htm
I found a possible risk to Methadone and Grapefruit juice here:
http://www.medicinenet.com/script/main/art.asp?articlekey=14760
Mayo states that grapefruits and grapefruit juice may increase the effects of transdermal fentanyl by increasing the amount of the medicine in your body. You should not eat grapefruit or drink grapefruit juice while you are using this medicine. See: http://www.mayoclinic.org/drugs-supplements/fentanyl-transdermal-route/precautions/drg-20068152