Maximizing Safety with Methadone & Other Opioids
Opioids provide life-saving analgesia for the millions of Americans who suffer with chronic pain, yet overdose deaths are rising at an alarming rate, with methadone implicated to a disproportionate degree [Paulozzi et al. 2006; Webster 2005; Warner et al. 2009]. Methadone deaths increased almost seven-fold from 790 in 1999 to 5,420 in 2006, rising faster More Info »
Oral Methadone Dosing for Chronic Pain: A Practitioner’s Guide
Methadone has emerged as a good choice for the management of cancer pain and chronic non-cancer pain both as a first-line medication and as a replacement opioid. Particular cautions must be observed as methadone’s pharmacokinetics and pharmacodynamics are unique among opioids. Milligram for milligram, however, methadone is much more powerful than morphine, although there is More Info »
Commonsense Opioid-Risk Management in Chronic Noncancer Pain: A Clinician’s Perspective
Chronic noncancer pain (CNP) is a serious and likely undertreated public health problem. In a 2005 survey, 19% of US adults reported chronic pain and 34% reported recurrent pain [Kuehn 2007]. The annual costs of pain-related healthcare, litigation, and compensation are estimated at $100 billion in the United States alone [Sinatra 2006]. While opioids have More Info »
Pain in Opioid-Addicted Patients Entering Addiction Treatment
Pain and addiction share some common physiologic pathways in the brain, especially those involving opioids, and each may affect the other. That is, the presence of pain may influence the development and course of opioid addiction, and vice versa (Compton and Gebhart 2003). These interactions may complicate therapy for opioid addiction. For example, opioid-addicted persons More Info »